Antibodies that detect TGF beta-1 can be used in several scientific applications, including Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry and ELISA. These antibodies target TGF beta-1 in Human, Mouse, Rat, Ovine and Mink samples. Our TGF beta-1...Antibodies that detect TGF beta-1 can be used in several scientific applications, including Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry and ELISA. These antibodies target TGF beta-1 in Human, Mouse, Rat, Ovine and Mink samples. Our TGF beta-1 polyclonal, monoclonal and recombinant monoclonal antibodies...Antibodies that detect TGF beta-1 can be used in several scientific applications, including Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry and ELISA. These antibodies target TGF beta-1 in Human, Mouse, Rat, Ovine and Mink samples. Our TGF beta-1 polyclonal, monoclonal and recombinant monoclonal antibodies are developed in Rabbit, Mouse and Chicken. These antibodies have been verified by Knockdown, Relative expression and Cell treatment to confirm specificity to TGF beta-1. Find the TGF beta-1 antibody that fits your needs. Choose from 1 of 54 TGF beta-1 antibodies, which have been validated in experiments with 59 publications and 109 images featured in our data gallery.
Browse primary antibodies for WB,...
Antibodies that detect TGF beta-1 can be used in several scientific applications, including Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry and ELISA. These antibodies target TGF beta-1 in Human, Mouse, Rat, Ovine and Mink samples. Our TGF beta-1 polyclonal, monoclonal and recombinant monoclonal antibodies are developed in Rabbit, Mouse and Chicken. These antibodies have been verified by Knockdown, Relative expression and Cell treatment to confirm specificity to TGF beta-1. Find the TGF beta-1 antibody that fits your needs. Choose from 1 of 54 TGF beta-1 antibodies, which have been validated in experiments with 59 publications and 109 images featured in our data gallery.
Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications.
靶标信息
TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.
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